Triumeq is a drug used as part of antiretroviral therapy (ART). Triumeq contains three antiretroviral drugs (ARVs) combined in one tablet:

The FDA approved Triumeq in 2014 as an ARV for people with HIV infection. Triumeq is manufactured by ViiV Healthcare.

Two of the drugs in Triumeq, abacavir and lamivudine, are nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs bind to and block reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating. The third drug in Triumeq, dolutegravir, is a type of drug called an integrase inhibitor. Integrase inhibitors block integrase (an HIV enzyme). HIV uses integrase to insert (integrate) its viral DNA into the DNA of host CD4 cells. Blocking integrase prevents HIV from replicating.

When used alone as a complete regimen or in combination with other ARVs to treat HIV infection, Triumeq may help:

    • Reduce the amount of HIV in your blood. This is called viral load.
    • Increase the number of CD4 cells in your blood that help fight off other infections.

Reducing the amount of HIV and increasing CD4 cells in your blood may help improve your immune system. This may reduce your risk of death or getting opportunistic infections (OIs) that can happen when your immune system is weak. Read more about viral suppression.

Triumeq does not cure HIV infection or AIDS. You must keep taking HIV medicines to control HIV infection and decrease HIV-related illnesses.


Triumeq is a three-drug fixed-dose combination medication that may be used alone as a complete HIV regimen or in combination with other ARVs to treat HIV infection in adults and in children who weigh at least 88 pounds (40 kg).

In some people, Triumeq should not be used by itself. Triumeq is not for use by itself in people who have or have had resistance to abacavir, dolutegravir, or lamivudine.

The safety and effectiveness of Triumeq has not been established in children who weigh less than 88 pounds (40 kg). Triumeq has not been carefully studied in the elderly (65 years of age and older).

All people with HIV should be on ART to keep healthy AND not transmit the virus to others. You and your healthcare provider should consider your CD4 cell count, your viral load, any symptoms you are having, and your preferences when deciding which HIV medications are right for you. Read more about U.S. ART guidelines.

Triumeq provides two drugs in one pill. It can be more convenient to use Triumeq than some other combinations of drugs that must be taken separately or at different times of the day. This could mean fewer missed doses and better control of HIV. Triumeq is used alone as a complete regimen or in combination with other ARVs for the treatment of HIV infection.


Do not take Triumeq if you:

    • Have a type of gene variation called the HLA-B*5701 allele. Your healthcare provider will test you for this before prescribing treatment with Triumeq.
    • Are allergic to abacavir, dolutegravir, lamivudine, or any of the ingredients in this drug.
    • Take dofetilide. Taking Triumeq and dofetilide can cause side effects that may be serious or life-threatening.
    • Have moderate or severe liver disease.


Before you take Triumeq, tell your healthcare provider about all of your medical conditions, and in particular if you:

Talk to your healthcare provider if you are pregnant, you plan to become pregnant, you become pregnant, or think you may be pregnant during treatment with Triumeq. One of the medicines in Triumeq called dolutegravir may harm your unborn baby. Your healthcare provider may prescribe a different medicine than Triumeq if you are planning to become pregnant or if pregnancy is confirmed during the first 12 weeks of pregnancy. If you can become pregnant, your healthcare provider will perform a pregnancy test before you start treatment with Triumeq and you should consistently use effective birth control (contraception) during treatment with Triumeq.

There is a pregnancy registry for people who take ARVs during pregnancy. The purpose of this registry is to collect information about the health of you and your baby and monitor outcomes in people exposed to ARVs during pregnancy. Talk to your healthcare provider about how you can take part in this registry. Read more about pregnancy and HIV.

Talk to your healthcare provider if you are breastfeeding or plan to breastfeed during treatment with Triumeq.  Two of the medicines in Triumeq (abacavir and lamivudine) pass to your baby in your breastmilk. Do not breastfeed if you have HIV because of the risk of passing HIV to your baby. Talk with your healthcare provider about the best way to feed your baby.


Many new copies of HIV are mutations. These new copies are slightly different from the original virus. Some mutations can keep multiplying even when you are taking an ARV. When this happens, the drug will stop working. This is called developing resistance to the drug. Sometimes, if your virus develops resistance to one ARV, it will also have resistance to other ARVs. This is called cross-resistance. Read more about HIV drug resistance.

Resistance can develop quickly. It is very important to take ARVs according
to instructions, on schedule, and not to skip or reduce doses.


Triumeq is taken by mouth as a tablet. Each Triumeq tablet contains 600 mg of abacavir, 50 mg of dolutegravir, and 300 mg of lamivudine. The recommended dosage of Triumeq for adults and children who weigh at least 88 pounds (40 kg) is one tablet once daily.

Take Triumeq at the same time each day with or without food.

If you take antacids, laxatives, or other medicines that contain aluminum, magnesium, or buffered medicines, Triumeq should be taken at least 2 hours before or 6 hours after you take these medicines.

If you need to take iron or calcium supplements by mouth during treatment with Triumeq:

    • If you take Triumeq with food, you may take these supplements at the same time that you take Triumeq.
    • If you do not take Triumeq with food, take Triumeq at least 2 hours before or 6 hours after you take these supplements.

If you take Triumeq with other ARVs, your healthcare provider will tell you what medicines to take and how to take them.


When you start any ARV, you may have temporary side effects such as headaches, nausea, indigestion, or a general sense of feeling ill. These side effects usually get better or disappear over time.

The most common side effects of Triumeq are trouble sleeping, tiredness or weakness, and headaches.

Triumeq can cause serious side effects, including:

Serious allergic reactions (hypersensitivity reaction). Serious allergic reactions (hypersensitivity reactions) that can cause death have happened with Triumeq and other abacavir-containing products. Your risk of this allergic reaction is much higher if you have a gene variation called HLA-B*5701. Your healthcare provider can determine with a blood test if you have this gene variation. If this test comes back positive, you should add Triumeq to the list of medications you are allergic to.

If you get a symptom from 2 or more of the following groups while taking Triumeq, call your healthcare provider right away to find out if you should stop taking Triumeq:

Group 1            Fever
Group 2            Rash
Group 3            Nausea, vomiting, diarrhea, abdominal (stomach area) pain
Group 4            Generally ill feeling, extreme tiredness, or achiness
Group 5            Shortness of breath, cough, sore throat

A list of these symptoms is on the Warning Card your pharmacist gives you. Carry this Warning Card with you at all times.

If you stop Triumeq because of an allergic reaction, never take Triumeq or any other abacavir-containing medicine (Ziagen, Epzicom, Trizivir) again. If you have an allergic reaction, dispose of any unused Triumeq. Ask your pharmacist how to properly dispose of medicines. If you take Triumeq or any other abacavir-containing medicine again after you have had an allergic reaction, within hours you may get life-threatening symptoms that may include very low blood pressure or death. If you stop Triumeq for any other reason, even for a few days, and you are not allergic to Triumeq, talk with your healthcare provider before taking it again. Taking Triumeq again can cause a serious allergic or life-threatening reaction, even if you never had an allergic reaction to it before.

Worsening of HBV infection. If you have HBV infection and take Triumeq, your HBV may get worse (flare-up) if you stop taking Triumeq. A flare-up is when your HBV infection suddenly returns in a worse way than before. Do not run out of Triumeq. Refill your prescription or talk to your healthcare provider before your Triumeq is all gone. Do not stop Triumeq without first talking to your healthcare provider. If you stop taking Triumeq, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver function and monitor your HBV infection. It may be necessary to give you a medicine to treat HBV. Tell your healthcare provider about any new or unusual symptoms you may have after you stop taking Triumeq.

Resistant HBV. If you have HIV and HBV, the HBV can change (mutate) during your treatment with Triumeq and become harder to treat (resistant).

Liver problems. People with a history of HBV or HCV may have an increased risk of developing new or worsening changes in certain liver function tests during treatment with taking Triumeq. Liver problems including liver failure have also happened with taking Triumeq in people without a history of liver disease or other risk factors. Liver failure resulting in liver transplant has also been reported with taking Triumeq. Your healthcare provider may do blood tests to check your liver. Tell your healthcare provider right away if you develop any of the signs or symptoms of liver problems listed below:

    • Your skin or the white part of your eyes turns yellow (jaundice)
    • Dark or “tea-colored” urine
    • Light-colored stools (bowel movements)
    • Loss of appetite for several days or longer
    • Nausea or vomiting
    • Pain, aching, or tenderness on the right side of your stomach area

Too much lactic acid in your blood (lactic acidosis). Lactic acidosis is a serious but rare medical emergency that can cause death. Tell your healthcare provider right away if you develop any of these symptoms:

    • Feel very weak or tired
    • Unusual (not normal) muscle pain
    • Trouble breathing
    • Stomach pain with nausea and vomiting
    • Feel cold, especially in your arms and legs
    • Feel dizzy or light-headed
    • Have a fast or irregular heartbeat

Lactic acidosis can also lead to severe liver problems, which can lead to death. Your liver may become large (hepatomegaly) and you may develop fat in your liver (steatosis). Call your healthcare provider right away if you get any of the signs or symptoms of liver problems which are listed above.

You may be more likely to get lactic acidosis or serious liver problems if you are assigned female at birth (AFAB) or are very overweight (obese).

Immune Reconstitution Inflammatory Syndrome (IRIS). IRIS is a side effect that can happen when you start taking HIV medications. Your immune system might get stronger and begin to fight infections that have been hidden in your body for a long time. This may result in an inflammatory response which may require further evaluation and treatment. Tell your healthcare provider right away if you experience any new symptoms after starting Triumeq.

Heart attack (myocardial infarction). Some HIV medicines including Triumeq may increase your risk of heart attack.

These are not all the possible side effects of abacavir. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


All ARVs can interact with other drugs or supplements you are taking. These interactions can change the amount of each drug in your bloodstream and cause an under- or overdose. New interactions are constantly being identified. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Your healthcare provider can tell you if it is safe to take Triumeq with other medicines.

Do not take Triumeq if you take dofetilide.

Research studies have identified drug interactions between abacavir and the following drugs: methadone and riociguat (Adempas). For some people taking abacavir-containing medicines such as Triumeq, an increased methadone dose may be required. For some people taking abacavir, the riociguat dose may need to be reduced.


Visit the Triumeq website.

Download the full Prescribing Information.

Download the Medication Guide.

Check out the ViiV Healthcare Patient Assistance Program.

Get a ViiV Healthcare Savings Card.

Reviewed March 2021

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