Ciprofloxacin, also called Cipro, is an antibiotic. Antibiotics fight infections caused by bacteria. Cipro fights many different bacteria. It is also used to fight some opportunistic infections (OIs) in people with HIV.

NOTE: In 2004, the Centers for Disease Control and Prevention (CDC) noted an increase in strains of gonorrhea that are resistant to Cipro among men who have sex with men (MSM). Using Cipro may be ineffective for gonorrhea and might actually increase the spread of drug-resistant gonorrhea. For this reason, the CDC recommends the use of other antibiotics by MSM for the treatment of gonorrhea.


Cipro is used for a wide range of bacterial infections. It works against many different bacteria. Cipro works against some bacteria that are resistant to other antibiotics, including penicillin.

Many germs live in our bodies or are common in our surroundings. A healthy immune system can fight them off or keep them under control. However, HIV infection can weaken the immune system. Infections that take advantage of weakened immune defenses are called opportunistic infections (OIs). People with advanced HIV disease can get OIs.

Cipro is often used along with other antibiotics to treat mycobacterium avium complex (MAC), an OI in people with HIV.

People who have a CD4 cell count less than 50 cells/mm3 may develop MAC. If your CD4 cell count is below 50 cells/mm3, talk to your healthcare provider about using Cipro.

Some people are allergic to Cipro and similar antibiotics. Be sure to tell your healthcare provider if you are allergic to any antibiotics.


Whenever you take medication, be sure to take all of the prescribed doses. Many people stop if they feel better, but this is not a good idea. If the drug doesn’t kill all of the germs, they might change (mutate) so that they can survive even when you are taking medications. When this happens, the drug will stop working. This is called developing resistance to the drug.

For example, if you are taking Cipro to fight MAC and you miss too many doses, the MAC in your body could develop resistance to Cipro. Then you would have to take a different drug or combination of drugs to fight MAC.


Cipro is available in several different strength tablets. They contain between 100 milligrams (mg) and 750 mg of Cipro. It is also available in a liquid form. Cipro is taken every 12 hours, except for a 500 mg once-daily formulation called Cipro XR. The dose of Cipro and the length of time you will take it depend on the type of infection you have.

Cipro tablets can be taken with or without food. Take them with plenty of water. Drink lots of water while you are taking Cipro to make sure the drug doesn’t accumulate in your kidneys.

Do not take Cipro at the same time as antacids that contain aluminum or magnesium. They will reduce the amount of Cipro in your blood.


The most common side effects of Cipro are nausea, diarrhea, vomiting, abdominal pain or discomfort, headache, rash, and restlessness. It can also cause dizziness and drowsiness. Very few people who take Cipro get these side effects. However, most antiretroviral medications (ARVs) used to treat HIV also cause problems in the digestive system. Cipro could make these problems worse. Cipro can cause nerve damage. If you have any numbness or tingling in your hands or feet, call your healthcare provider immediately.

Cipro makes some people very sensitive to sunlight. It increases the effects of caffeine and can make you very jittery and nervous. In rare cases, Cipro causes an allergic reaction that can be serious.

Antibiotics kill some helpful bacteria that normally live in the digestive system. You can eat yogurt or take supplements of acidophilus to replace them.


Cipro is not broken down by the liver. This means that it does not have many interactions with ARVs. However, it is still a good idea to tell your healthcare provider about all the medications you are taking.

Antacids that contain aluminum or magnesium can lower blood levels of Cipro. Do not take antacids at the same time as Cipro.

Supplements that contain calcium, iron, or zinc can also reduce levels of Cipro. Do not take them while you are taking Cipro. Ask your healthcare provider whether you should keep taking multivitamins that contain iron, calcium, or zinc while you are taking Cipro.

Probenecid is a drug used to lower uric acid levels. This is a treatment for gout. Probenecid causes large increases in the blood levels of Cipro.

Cipro can increase methadone levels, possibly causing a serious overdose. 


Ciprofloxacin is used to treat MAC, an opportunistic infection in people with HIV. It can treat active infections. If your CD4 cell count is below 300 cells/mm3, talk to your healthcare provider about taking drugs to prevent MAC.


MedlinePlus: Ciprofloxacin

Drugs.com: Ciprofloxacin

Reviewed March 2021

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