Long-acting injectable antivirals for PrEP (LAI-PrEP) are a paradigm shift in HIV combination prevention. They have the potential to improve adherence and transform the way PrEP is delivered. Long acting Cabotegravir (CAB-LA) was shown to be superior to oral PrEP and safe and effective among cisgender women, cisgender men who have sex with men, and transgender women who have sex with men in two landmark randomized controlled trials, HPTN 083 and HPTN 084. In HPTN 083, CAB-LA reduced the risk of sexually acquired HIV by 66% compared to daily oral PrEP. In HPTN 084, the risk of acquiring HIV was reduced by 89% for those receiving CAB-LA compared to daily oral PrEP. Long-acting injectable products have been reported to be acceptable and preferred in studies examining PrEP preferences and may reach new and hard-to-reach individuals who would benefit from effective HIV prevention. Despite being a key component of the federal National HIV/AIDS Strategy and the Ending the HIV Epidemic Initiative (EHE), PrEP uptake in the U.S has been sub-optimal with the Centers for Disease Control and Prevention (CDC) estimating that about 300,800 people were prescribed PrEP in 2020, representing only 25% of those with an indication for its use. Access to PrEP is inequitable, with only 8% of African Americans and 14% of Hispanics/Latinos eligible for PrEP being prescribed it in 2019, compared to 63% of white Americans. Similarly, uptake of PrEP among trans people is low. Communities of color have been reported to be underrepresented in PrEP uptake as are people residing in the Southern U.S., in part because of a lack of awareness of PrEP in these population groups. There is a need for ongoing implementation science to better understand the values and preferences of providers and individuals at risk for HIV acquisition and the factors needed to create an enabling environment and how services need to be adapted for its delivery in specialized and primary care settings. Simplification of PrEP delivery is one key to improving uptake, especially in the hardest-to reach populations.


Strengthening Capacity to Implement Long-Acting Injectable-PrEP in Ryan White Care Act (RWCA) Clinics is a web-based activity to build capacity among clinicians for accelerated implementation of long-acting injectable HIV prevention (LAI-PrEP). The activity’s educational focus includes:

  1. An overview of the paradigm shift in biomedical HIV prevention with LAI-PrEP
  2. Benefits and risks of switching from an oral to an LAI-PrEP regimen
  3. Requirements to adapt services to initiate and maintain reliable delivery of LAI-PrEP
  4. Communication strategies to increase patient acceptability of injectable LAI-PrEP
  5. Management strategies to deliver LAI-PrEP with cultural competence
  6. Implementation strategies to optimize LAI-PrEP persistence and adherence
  7. Addressing stigma and other challenges in transitioning from an oral to LAI-PrEP regimen
  8. Management strategies to respond to missed doses and discontinuation of LAI-PrEP (when indicated).

Planning Committee

This educational activity was developed by a course director and an activity manager:

Course Director: Christopher Duncombe, MD, AM (University of Washington, Seattle, WA, USA)
Faculty: Rupa Patel, MD, MPH (US Centers for Disease Control and Prevention, Atlanta, GA, USA)
Activity Manager: Jonathon Hess, MPA, LLM (International Association of Providers of AIDS Care, Washington, DC, USA)
Activity Assistant: Cassandra Moore, MPH (International Association of Providers of AIDS Care, Washington, DC, USA)



This CME activity is provided by Albert Einstein College of Medicine-Montefiore Medical Center in joint providership with the International Association of Providers of AIDS Care (IAPAC).

Commercial Support Acknowledgement

Educational grant from ViiV Healthcare.

Target Audience

This activity has been designed to meet the educational needs of HIV care providers and other healthcare professionals providing HIV care and treatment such as physicians, nurse practitioners, and physician assistants.

Learning Objectives

Upon successful completion of this activity, learners should be able to:

  1. Describe how LAI-PrEP is prescribed and monitored
  2. List which patients would benefit from initiating LAI-PrEP and switching from oral PrEP to LAI-PrEP
  3. Describe who are the hardest-to-reach populations and strategies to engage them in care
  4. Explain how hard-to-reach populations may benefit from LAI-PrEP
  5. Describe how to minimize the risk of LAI-PrEP drug resistance

Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and the International Association of Providers of AIDS Care (IAPAC). Albert Einstein College of Medicine-Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation Statements

Physicians Albert Einstein College of Medicine-Montefiore Medical Center designates this live activity for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Financial Relationships

Planners, faculty members and peer reviewers have no relevant financial relationships with ACCME-defined ineligible companies during the past 24 months.

The “Policy on Identification, Mitigation and Disclosure of Relevant Financial Relationships” of Albert Einstein College of Medicine-Montefiore Medical Center requires that any individual in control of content, including faculty, participating in CME/CE activities disclose to the audience all relevant financial relationships with ineligible companies* in the last 24 months.

Any individual in control of content who refuses to disclose, or their disclosed relationships prove to create a conflict of interest will be recused. Individuals with the absence of relevant financial relationships with ineligible companies will be disclosed to the audience.

All financial relationships of individuals in a position to control the content of this CME/CE activity has been identified and mitigated prior to this educational activity.

*The ACCME defines an ineligible company as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Course Content

This activity’s three modules are covered in the course content link below, which should be fully reviewed prior to completing the knowledge assessment. If you encounter any issues, please contact Jonathon Hess, MPA, LLM, IAPAC Senior Director of Education, at

Knowledge Assessment

This activity has a knowledge assessment. The assessment requires completing 30 multiple choice questions covering topics covered in the activity’s three modules and must be completed following the activity’s completion to claim 2.0 AMA PRA Category 1 Credits™.